N-Methyl-N-(trifluoromethylthio)aniline

Base Information

• Chemical Name: N-Methyl-N-(trifluoromethylthio)aniline
• CAS No.: 66476-44-6
• Molecular Formula: C₈H₈F₃NS
• Molecular Weight: 207.219
• Hs Code.: 2930909899
• Mol file: 66476-44-6.mol

Synonyms:N-methyl-N-phenyl-S-(trifluoromethyl)thiohydroxylamine

Chemical Property of N-Methyl-N-(trifluoromethylthio)aniline

Chemical Property:

• Refractive Index: 1.4920 to 1.4960
• Boiling Point: 151.2±50.0 °C(Predicted)
• PKA: -0.18±0.50(Predicted)
• Density: 1.313±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl-N-(trifluoromethylthio)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Methyl-N-(trifluoromethylthio)aniline is a useful research chemical.

Technology Process of N-Methyl-N-(trifluoromethylthio)aniline

There total 8 articles about N-Methyl-N-(trifluoromethylthio)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(benzenesulfonyl)-N-[(trifluoromethyl)sulfanyl]benzenesulfonamide + N-methylaniline (100-61-8) → N-methyl-N-phenyl-S-(trifluoromethyl)thiohydroxylamine (66476-44-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.joc.6b01178

Reference yield: 90.0%

N-[(trifluoromethyl)sulfanyl]aniline (1045821-71-3) + methyl iodide (74-88-4) → N-methyl-N-phenyl-S-(trifluoromethyl)thiohydroxylamine (66476-44-6)

Guidance literature:

N-[(trifluoromethyl)sulfanyl]aniline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -20 - -10 ℃; for 0.166667h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at -20 - 20 ℃; for 4.5h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.oprd.6b00062

Reference yield: 86.0%

2-diazo-1-phenyl-2-((trifluoromethyl)sulfonyl)ethan-1-one (1140280-85-8) + N-methylaniline (100-61-8) → N-methyl-N-phenyl-S-(trifluoromethyl)thiohydroxylamine (66476-44-6)

Guidance literature:

With copper (II)-fluoride; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1002/open.201500225

upstream raw materials:

Trifluoromethylsulfenyl chloride

N-methylaniline

N-((trifluoromethyl)thio)isoindoline-1,3-dione

N-[(trifluoromethyl)sulfanyl]aniline

Downstream raw materials:

N-benzyl-1-phenyl-N-[(trifluoromethyl)sulfanyl]methanamine

N-[(trifluoromethyl)sulfanyl]aniline

S-(trifluoromethyl) benzenesulfonothioate