[1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Base Information

• Chemical Name: [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid
• CAS No.: 128693-75-4
• Molecular Formula: C₂₆H₂₇N₂O₄P
• Molecular Weight: 462.485
• Mol file: 128693-75-4.mol

Synonyms:[1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Chemical Property of [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

There total 6 articles about [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

5-phthalimido-1-pentanal (95691-09-1) + Benzhydrylamine (91-00-9) → [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid (128693-75-4)

Guidance literature:

With hypophosphorous acid; In ethanol; at 80 ℃;

DOI:10.1039/a704097k

Reference yield: 35.0%

5-phthalimido-1-pentanal (95691-09-1) + benzhydrylamine hydrophosphorous acid salt → [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid (128693-75-4)

Guidance literature:

In 1,4-dioxane; at 100 ℃;

Reference yield:

phthalic anhydride (85-44-9) → [1-(Benzhydryl-amino)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid (128693-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / toluene / Heating

2: 1.) Me₂SO, (COCl)2, 2.) Et₃N / 1.) -78 deg C

3: 36 percent / H₃PO₂ / aq. ethanol / 80 °C

With oxalyl dichloride; hypophosphorous acid; dimethyl sulfoxide; triethylamine; In ethanol; toluene;

DOI:10.1039/a704097k

upstream raw materials:

5-phthalimido-1-pentanal

Benzhydrylamine

phthalic anhydride

5-hydroxypentylamine

Downstream raw materials:

[5-Amino-1-(benzhydryl-amino)-pentyl]-phosphinic acid

[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-hydroxy-phosphinoyl}-2-methyl-propionic acid methyl ester

(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester