cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

Base Information

Chemical Name:cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide
CAS No.:1343456-03-0
Molecular Formula:C₂₅H₃₀ClN₃O₄S
Molecular Weight:504.05
Hs Code.:

Synonyms:cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

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Chemical Property of cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

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Technology Process of cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

There total 7 articles about cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 154350-29-5
cyclopropanesulphonamide

: 1343455-94-6
2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid

: 1343456-03-0
cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; at 65 ℃; for 12h;

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 1343456-03-0
cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 2 h / Reflux

2: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 5 h / 25 °C

3: trifluoroacetic acid; triethylsilane / 1 h / 25 °C

4: potassium hydroxide / L-proline; copper(l) iodide / dimethyl sulfoxide / 4 h / 120 °C

5: water; lithium hydroxide monohydrate / ethanol; tetrahydrofuran / 12 h / 60 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 12 h / 65 °C

With triethylsilane; lithium hydroxide monohydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; dmap; copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; L-proline; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2: Diels-Alder Reaction / 4: Ullmann Reaction;

Reference yield:

: 188813-05-0
3-bromo-5-chloro-benzaldehyde

: 1343456-03-0
cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 2 h / Reflux

2: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 5 h / 25 °C

3: trifluoroacetic acid; triethylsilane / 1 h / 25 °C

4: potassium hydroxide / L-proline; copper(l) iodide / dimethyl sulfoxide / 4 h / 120 °C

5: water; lithium hydroxide monohydrate / ethanol; tetrahydrofuran / 12 h / 60 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 12 h / 65 °C

With triethylsilane; lithium hydroxide monohydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; dmap; copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; L-proline; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2: Diels-Alder Reaction / 4: Ullmann Reaction;