C₃₇H₆₅NO₈Si₂

Base Information

Chemical Name:C₃₇H₆₅NO₈Si₂
CAS No.:1332721-83-1
Molecular Formula:C₃₇H₆₅NO₈Si₂
Molecular Weight:708.096
Hs Code.:

C<sub>37</sub>H<sub>65</sub>NO<sub>8</sub>Si<sub>2</sub>

Synonyms:C₃₇H₆₅NO₈Si₂

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Chemical Property of C₃₇H₆₅NO₈Si₂

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Technology Process of C₃₇H₆₅NO₈Si₂

There total 18 articles about C₃₇H₆₅NO₈Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1332721-82-0
(2S,3S,4R)-(triisopropylsilyloxy)methyl 3-((1S,3R)-3-((benzyloxy)methyl)-1-methoxybutyl)-3-hydroxy-2-(hydroxymethyl)-1,4-dimethyl-5-oxopyrrolidine-2-carboxylate

: 85272-30-6
diisopropylsilanediyl bistriflate

: 1332721-83-1
C₃₇H₆₅NO₈Si₂

Guidance literature:: With 2,6-dimethylpyridine; In 1,2-dichloro-ethane; for 2h; Reflux; Inert atmosphere;
DOI:10.1021/ol202306d

Reference yield:

: 955959-57-6
C₂₀H₂₅NO₇

: 1332721-83-1
C₃₇H₆₅NO₈Si₂

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 45 h / 0 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 33 h / 0 - 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 6.5 h / -78 °C / Inert atmosphere

5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 38 h / 0 °C / Molecular sieve; Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

7.1: Jones reagent / acetone / 0.5 h / 0 °C / Inert atmosphere

8.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 5 h / 0 - 20 °C / Inert atmosphere

9.1: zirconium(IV) chloride / isopropyl alcohol / 9 h / Reflux; Inert atmosphere

10.1: tetrabutyl ammonium fluoride; triethylamine; copper(ll) bromide / dichloromethane / 2 h / 0 - 20 °C / Molecular sieve; Darkness; Inert atmosphere

11.1: 2,6-dimethylpyridine / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

With 2,6-dimethylpyridine; sodium chlorite; sodium tetrahydroborate; Jones reagent; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; zirconium(IV) chloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; tert-butyl alcohol; 7.1: Jones oxidation / 8.1: Pinnick oxidation;
DOI:10.1021/ol202306d

Reference yield:

: 955959-40-7
(3R,3aS,4S,6aR)-methyl 4-((R)-3-(benzyloxy)-2-methylpropyl)-hexahydro-3a-hydroxy-1,3-dimethyl-2,6-dioxo-1H-furo[3,4-b]pyrrole-6a-carboxylate

: 1332721-83-1
C₃₇H₆₅NO₈Si₂

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 45 h / 0 - 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 33 h / 0 - 20 °C / Inert atmosphere

5.1: 2,6-dimethylpyridine / dichloromethane / 6.5 h / -78 °C / Inert atmosphere

6.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 38 h / 0 °C / Molecular sieve; Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

8.1: Jones reagent / acetone / 0.5 h / 0 °C / Inert atmosphere

9.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 5 h / 0 - 20 °C / Inert atmosphere

10.1: zirconium(IV) chloride / isopropyl alcohol / 9 h / Reflux; Inert atmosphere

11.1: tetrabutyl ammonium fluoride; triethylamine; copper(ll) bromide / dichloromethane / 2 h / 0 - 20 °C / Molecular sieve; Darkness; Inert atmosphere

12.1: 2,6-dimethylpyridine / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

With 2,6-dimethylpyridine; sodium chlorite; sodium tetrahydroborate; Jones reagent; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; zirconium(IV) chloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; tert-butyl alcohol; 8.1: Jones oxidation / 9.1: Pinnick oxidation;
DOI:10.1021/ol202306d