(S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

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Chemical Name:(S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate
CAS No.:140677-43-6
Molecular Formula:C₂₀H₂₃N₃O₅
Molecular Weight:385.42
Hs Code.:

Synonyms:(S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

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Chemical Property of (S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

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Technology Process of (S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

There total 8 articles about (S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 140677-48-1
(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

: 140677-43-6
(S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 50 ℃; for 0.25h;
DOI:10.1021/jo00039a007

Reference yield: 61.0%

: 105-36-2
ethyl bromoacetate

: 140677-47-0
(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

: 140677-43-6
(S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

Guidance literature:: With sodium ethanolate; In ethanol; at 40 ℃;
DOI:10.1021/jo00039a007

Reference yield:

: 58456-26-1
(S)-4-<2'-(Chloroformyl)ethyl>-5-oxooxazolidin-3-carbonsaeure-benzylester

: 140677-43-6
(S)-ethyl 3-((benzyloxycarbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, r.t., 30 min, 2) THF, -65 deg C, 1 h

2: 12 percent / NaOAc / methanol / 0.5 h / 50 °C

3: 66 percent / 20percent HCl / tetrahydrofuran / 0.25 h / 50 °C

With hydrogenchloride; sodium acetate; magnesium; In tetrahydrofuran; methanol;
DOI:10.1021/jo00039a007