3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone

Base Information

Chemical Name:3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
CAS No.:162011-91-8
Molecular Formula:C₁₇H₁₃ClO₄S
Molecular Weight:348.807
Hs Code.:
ChEMBL ID:CHEMBL2403541
DSSTox Substance ID:DTXSID501178819

Synonyms:SCHEMBL3240070;CHEMBL2403541;DTXSID501178819;3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;162011-91-8

Suppliers and Price of 3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:348.0223078
Heavy Atom Count:23
Complexity:597

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3Cl

Technology Process of 3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone

There total 5 articles about 3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2444-36-2
2'-chloro-benzeneacetic acid

: 50413-24-6
2-bromo-1-(4-methanesulfonylphenyl)ethanone

: 162011-91-8
3-(2-Chlorophenyl)-4-(4-(Methylsulfonyl)Phenyl)-2-(5H)-Furanone

Guidance literature:: 2'-chloro-benzeneacetic acid; With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

2-bromo-1-(4-methanesulfonylphenyl)ethanone; In N,N-dimethyl-formamide; for 1h;

With diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.04.062

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 162011-91-8
3-(2-Chlorophenyl)-4-(4-(Methylsulfonyl)Phenyl)-2-(5H)-Furanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C

2.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C

2.2: 2.5 h / 25 - 58 °C

3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h

3.3: 4 h / 60 °C

With sulfuric acid; hydrogen bromide; dihydrogen peroxide; acetic acid; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.062

Reference yield:

: 10297-73-1
4-(methanesulfonyl)acetophenone

: 162011-91-8
3-(2-Chlorophenyl)-4-(4-(Methylsulfonyl)Phenyl)-2-(5H)-Furanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C

1.2: 2.5 h / 25 - 58 °C

2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 1 h

2.3: 4 h / 60 °C

With hydrogen bromide; acetic acid; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.062