3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid

Base Information

• Chemical Name: 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid
• CAS No.: 282524-78-1
• Molecular Formula: C₂₅H₂₃NO₄
• Molecular Weight: 401.462
• DSSTox Substance ID: DTXSID20404127
• Nikkaji Number: J1.079.786A
• Mol file: 282524-78-1.mol

Synonyms:282524-78-1;3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid;3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-phenylbutanoic acid;3-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)-4-PHENYLBUTANOIC ACID;3-(9 h-fluoren-9-ylmethoxycarbonylamino)-4-phenyl-butyric acid;3-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-phenylbutyric acid;Fmoc-beta-Hophe-OH;MFCD04117843;(S)-3-(Fmoc-amino)-4-phenylbutyric acid;(r)-3-(fmoc-amino)-4-phenylbutanoic acid;Fmoc-L-|A-homophenylalanine;SCHEMBL3207886;DTXSID20404127;BCP11554;MFCD02090627;3-(Fmoc-amino)-4-phenylbutanoic acid;AKOS026739785;AB88508;AB89155;Fmoc-(S)-3-Amino-4-phenylbutyric acid;AS-72198;HEXAFLUOROISOPROPYL2-FLUOROACRYLATE;SY064086;SY109254;CS-0169310;FT-0644333;FT-0652229;FT-0657191;C74454;EN300-650359;3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoicacid;3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-phenylbutanoic acid

Chemical Property of 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid

Chemical Property:

• PSA: 75.63000
• LogP: 5.00200
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 401.16270821
• Heavy Atom Count: 30
• Complexity: 566

Purity/Quality:

99% ^*data from raw suppliers

3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(CC(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid

There total 16 articles about 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-1-diazo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-phenylbutan-2-one (172097-41-5) → (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid (193954-28-8,282524-78-1)

Guidance literature:

With water; silver trifluoromethanesulfonate; In 1,4-dioxane; for 72h; sonication;

DOI:10.1021/ja029205t

Reference yield: 84.0%

(±)-(9H-fluoren-9-yl)methyl 3-benzyl-5-oxoisoxazolidine-2-carboxylate → (±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid (282524-78-1)

Guidance literature:

With acetic acid; zinc; In tetrahydrofuran; water; at 40 ℃; for 4h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201700472

Reference yield: 58.0%

allyl (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoate → (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid (193954-28-8,282524-78-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; In dichloromethane; for 0.166667h;

DOI:10.1016/S0040-4020(01)00731-1

upstream raw materials:

(S)-1-diazo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-phenylbutan-2-one

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(S)-3-amino-4-phenylbutanoic acid trifluoroacetate

N-Fmoc L-Phe

Downstream raw materials:

C₁₁₅H₁₆₁N₁₇O₂₇S₂

C₇₃H₁₁₇N₉O₁₆

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