2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Base Information

Chemical Name:2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile
CAS No.:181579-48-6
Molecular Formula:C₂₃H₃₁N₅
Molecular Weight:377.533
Hs Code.:

Synonyms:2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

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Chemical Property of 2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

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Technology Process of 2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

There total 5 articles about 2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 7677-24-9
trimethylsilyl cyanide

: 67-64-1
acetone

: 179558-09-9
1-benzyl-4-[N-ethyl-N-(3-amino-2-pyridinyl)amino]piperidine

: 181579-48-6
2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Guidance literature:: With zinc(II) chloride;
DOI:10.1021/jm960158n

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 181579-48-6
2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

2: 84 percent / lithium aluminum hydride / tetrahydrofuran / 16 h / Heating

3: 69 percent / K₂CO₃ / acetonitrile / 72 h / Heating

4: H₂ / platinum oxide / methanol

5: 85 percent / ZnCl₂

With pyridine; lithium aluminium tetrahydride; hydrogen; potassium carbonate; zinc(II) chloride; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm960158n

Reference yield:

: 50534-23-1
4-acetylamino-1-benzylpiperidine

: 181579-48-6
2-{2-[(1-Benzyl-piperidin-4-yl)-ethyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / lithium aluminum hydride / tetrahydrofuran / 16 h / Heating

2: 69 percent / K₂CO₃ / acetonitrile / 72 h / Heating

3: H₂ / platinum oxide / methanol

4: 85 percent / ZnCl₂

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; zinc(II) chloride; platinum(IV) oxide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm960158n