tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

Base Information

Chemical Name:tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate
CAS No.:1318792-84-5
Molecular Formula:C₂₈H₃₆N₆O₄
Molecular Weight:520.632
Hs Code.:

Synonyms:tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

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Chemical Property of tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

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Technology Process of tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

There total 9 articles about tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 486422-03-1
3-amino-6-bromo-N-pyridin-3-ylpyrazine-2-carboxamide

: 1318792-82-3
tert-butyl-(3-methoxypropyl)-N-{3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propyl}carbamate

: 1318792-84-5
tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

Guidance literature:: With tripotassium phosphate "n" hydrate; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; In water; butan-1-ol; at 80 ℃; for 2h; Product distribution / selectivity; Inert atmosphere; Industry scale;

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 1318792-84-5
tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 16 h / 80 - 90 °C / Inert atmosphere

3: sodium hydroxide / water; tetrahydrofuran / 1 h / 10 °C / Inert atmosphere

4: potassium acetate / tricyclohexylphosphine; palladium dichloride / acetonitrile / 16 h / 80 °C / Inert atmosphere

5: tripotassium phosphate "n" hydrate / sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid / butan-1-ol; water / 2 h / 80 °C / Inert atmosphere; Industry scale

With tripotassium phosphate "n" hydrate; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; palladium dichloride; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; acetonitrile; butan-1-ol;

Reference yield:

: 1643-30-7
3-(4-bromophenyl)propionic acid

: 1318792-84-5
tert-butyl N-[3-{4-[5-amino-6-(3-pyridylcarbamoyl)pyrazin-2-yl]phenyl}propyl]-N-(3-methoxypropyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Reflux; Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 16 h / 80 - 90 °C / Inert atmosphere

4.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 10 °C / Inert atmosphere

5.1: potassium acetate / tricyclohexylphosphine; palladium dichloride / acetonitrile / 16 h / 80 °C / Inert atmosphere

6.1: tripotassium phosphate "n" hydrate / sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid / butan-1-ol; water / 2 h / 80 °C / Inert atmosphere; Industry scale

With lithium aluminium tetrahydride; tripotassium phosphate "n" hydrate; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; palladium dichloride; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; acetonitrile; butan-1-ol;