N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Base Information

Chemical Name:N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide
CAS No.:1541832-07-8
Molecular Formula:C₂₂H₂₃FN₄O₆S
Molecular Weight:490.512
Hs Code.:

Synonyms:N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

There total 6 articles about N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1541832-56-7
N-(2-nitrooxyethyl)-2-(tert-butoxy)carbonylamino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

: 1541832-07-8
N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Guidance literature:: With trifluoroacetic acid; In 1,4-dioxane; at 60 ℃; for 0.666667h; under 8791.75 Torr; Microwave irradiation;
DOI:10.1016/j.bmc.2013.12.008

Reference yield:

: ethyl 2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]-2-(hydroxylamino)ylidene-acetate

: 1541832-07-8
N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: formic acid; zinc / ethanol / 20 h / 0 - 20 °C

2: hydrogenchloride / methanol / 18 h / 20 °C

3: water; sodium hydroxide / methanol / 17 h / 20 °C

4: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / 1,4-dioxane / 0.67 h / 60 °C / 8791.75 Torr / Microwave irradiation

With hydrogenchloride; dmap; formic acid; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2013.12.008

Reference yield:

: 1415910-80-3
C₂₇H₃₁FN₂O₆S

: 1541832-07-8
N-(2-nitroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / methanol / 17 h / 20 °C

2: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / 1,4-dioxane / 0.67 h / 60 °C / 8791.75 Torr / Microwave irradiation

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmc.2013.12.008