2,3,6-trimethoxytoluene

Base Information

• Chemical Name: 2,3,6-trimethoxytoluene
• CAS No.: 25576-97-0
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.219
• Mol file: 25576-97-0.mol

Synonyms:2,3,6-trimethoxytoluene

Chemical Property of 2,3,6-trimethoxytoluene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,6-trimethoxytoluene

There total 16 articles about 2,3,6-trimethoxytoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2,4-trimethoxy-benzene (135-77-3) + methyl iodide (74-88-4) → 2,3,6-trimethoxytoluene (25576-97-0)

Guidance literature:

1,2,4-trimethoxy-benzene; With n-butyllithium;

methyl iodide;

Reference yield: 87.0%

2,4-dimethoxy-3-methylphenol (19676-67-6) + methyl iodide (74-88-4) → 2,3,6-trimethoxytoluene (25576-97-0)

Guidance literature:

With barium dihydroxide; In N,N-dimethyl-formamide; for 9h; Ambient temperature;

DOI:10.1021/jo00326a029

Reference yield:

2,4-dimethoxy-3-methylphenol (19676-67-6) + dimethyl sulfate (77-78-1) → 2,3,6-trimethoxytoluene (25576-97-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(96)02065-5

upstream raw materials:

1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone

2-methoxy-3-methylbenzene-1,4-diol

dimethyl sulfate

methyl bromide

Downstream raw materials:

2,4,5-trimethoxy-3-methylbenzaldehyde

1-Iodo-2,4,5-trimethoxy-3-methyl-benzene

(S)S-2-methyl-5-p-tolylsulfinyl-1,3,4-trimethoxybenzene

6-acetyl-3,4-dimethoxy-2-methylphenol

Refernces

• 1、 O'Hora, Paul S.,Incerti-Pradillos, Celia A.,Kabeshov, Mikhail A.,Shipilovskikh, Sergei A.,Rubtsov, Aleksandr E.,Elsegood, Mark R. J.,Malkov, Andrei V.. "Catalytic Asymmetric Crotylation of Aldehydes: Application in Total Synthesis of (-)-Elisabethadione". supporting information. p. 4551 - 4555. Retrieved 2015/03/18.
• 2、 Alves, Ana P. L.,Junior, Jose Augusto B. C.,Slana, Glaucia B. A.,Cardoso, Jari N.,Wang, Qiang,Lopes, Rosangela S. C.,Lopes, Claudio C.. "Synthesis of 1,2,4-trimethoxybenzene and its selective functionalization at C-3 by directed metalation". experimental part. p. 3693 - 3709. Retrieved 2009/12/06.