Z-NLE-OSU

Base Information

• Chemical Name: Z-NLE-OSU
• CAS No.: 36360-62-0
• Molecular Formula: C18H22 N2 O6
• Molecular Weight: 362.38
• Mol file: 36360-62-0.mol

Synonyms:Z-L-2-AMINOHEXANOIC ACID-N-HYDROXYSUCCINIMIDE ESTER;Z-L-NORLEUCINE N-HYDROXYSUCCINIMIDE ESTER;Z-NLE-OSU;Z-NORLEUCINE-OSU;Z-L-2-aminohexanoic acid-N-hydroxysuccinimide este

Chemical Property of Z-NLE-OSU

Chemical Property:

• PKA: 10.60±0.46(Predicted)
• PSA: 105.50000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 2.22110
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Z-L-norleucine N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-NLE-OSU

There total 1 articles about Z-NLE-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-benzyloxycarbonyl-L-norleucine (39608-30-5) → N-benzyloxycarbonyl-L-norleucine succinimide ester (36360-62-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00391a017

Reference yield: 82.7%

N-benzyloxycarbonyl-L-norleucine succinimide ester (36360-62-0) + L-Norleucine (327-57-1) → N-benzyloxycarbonyl-L-norleucyl-L-norleucine (252573-92-5)

Guidance literature:

With triethylamine; In 1,2-dimethoxyethane; water; at 20 ℃;

DOI:10.1021/jm990226g

Reference yield: 80.0%

N-benzyloxycarbonyl-L-norleucine succinimide ester (36360-62-0) + L-prolinamide (7531-52-4) → N-benzyloxycarbonyl-L-norleucyl-L-prolinamide

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/jm0500830

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-benzyloxycarbonyl-L-norleucine

Downstream raw materials:

Z-Nle-D-Ala-Trp-Nle-Asp-Phe-NH₂

N-benzyloxycarbonyl-L-norleucyl-L-norleucine

N-benzyloxycarbonyl-L-norleucyl-L-norleucine methylamide

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