4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

Base Information

• Chemical Name: 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide
• CAS No.: 139982-02-8
• Molecular Formula: C₂₂H₁₅F₆N₅O
• Molecular Weight: 479.384
• Mol file: 139982-02-8.mol

Synonyms:4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

Chemical Property of 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

There total 5 articles about 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

potassium cyanide (151-50-8) + 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139981-81-0) → 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139982-02-8)

Guidance literature:

With potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 110 ℃;

DOI:10.1016/0960-894X(96)00137-0

Reference yield: 28.0%

potassium cyanide (151-50-8) + 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139981-81-0) → 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139982-02-8) + N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide (139982-01-7)

Guidance literature:

With potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 130 - 140 ℃;

DOI:10.1016/S0968-0896(97)00058-8

Reference yield:

α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine (81659-38-3) → 4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139982-02-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Heating

2: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, overnight

4: 8 percent / KI, K₂CO₃ / dimethylsulfoxide / 130 - 140 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/S0968-0896(97)00058-8

upstream raw materials:

potassium cyanide

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-benzamide

Downstream raw materials:

2-(4-cyanophenyl)-4,5-dihydro-N,1-dimethyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-amine

trans-N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide