Benzamide, 4-fluoro-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluorometh yl)-1H-imidazol-5-yl]-N-methyl-

Base Information

• Chemical Name: Benzamide, 4-fluoro-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluorometh yl)-1H-imidazol-5-yl]-N-methyl-
• CAS No.: 139981-81-0
• Molecular Formula: C20H15F8N3O
• Molecular Weight: 465.346
• Mol file: 139981-81-0.mol

Synonyms:

Chemical Property of Benzamide, 4-fluoro-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluorometh yl)-1H-imidazol-5-yl]-N-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 4-fluoro-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluorometh yl)-1H-imidazol-5-yl]-N-methyl-

There total 3 articles about Benzamide, 4-fluoro-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluorometh yl)-1H-imidazol-5-yl]-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-benzamide (139981-80-9) + methyl iodide (74-88-4) → 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139981-81-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/0960-894X(96)00137-0

Reference yield:

α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine (81659-38-3) → 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139981-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Heating

2: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, overnight

With lithium aluminium tetrahydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0968-0896(97)00058-8

Reference yield:

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-(4Z)-ylidene]-benzamide → 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide (139981-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, overnight

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0968-0896(97)00058-8

upstream raw materials:

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-benzamide

methyl iodide

α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

Downstream raw materials:

4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

2-(4-cyanophenyl)-4,5-dihydro-N,1-dimethyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-amine

[2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-methyl-amine