7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

Base Information

Chemical Name:7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione
CAS No.:80092-93-9
Molecular Formula:C₂₀H₁₃ClF₃NO₂
Molecular Weight:391.777
Hs Code.:

Synonyms:7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

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Technology Process of 7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

There total 6 articles about 7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 53966-34-0
3-(4-trifluoromethylphenyl)-7-chloro-10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-dione

: 80092-93-9
7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

Guidance literature:: With phosphorus trichloride; In chloroform; for 1h; Heating;
DOI:10.1021/jm00097a001

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 80092-93-9
7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

Guidance literature:: Multi-step reaction with 6 steps

1: 32 percent / 50percent aq. NaOH / 72 h / Ambient temperature

2: EtONa / ethanol / 6 h / Heating

3: 2 N NaOH / 2 h / Heating

4: 5 N H₂SO₄ / 4.5 h / Heating

5: 55 percent / concd HCl, glacial AcOH / 4 h / 85 °C

6: 66 percent / PCl₃ / CHCl₃ / 1 h / Heating

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium ethanolate; acetic acid; phosphorus trichloride; In ethanol; chloroform;
DOI:10.1021/jm00097a001

Reference yield:

: 55579-69-6
5-<4-(trifluoromethyl)phenyl>-1,3-cyclohexanedione

: 80092-93-9
7-chloro-3,4-dihydro-3-<4-(trifluoromethyl)phenyl>-1,9(2H,10H)-acridinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / concd HCl, glacial AcOH / 4 h / 85 °C

2: 66 percent / PCl₃ / CHCl₃ / 1 h / Heating

With hydrogenchloride; acetic acid; phosphorus trichloride; In chloroform;
DOI:10.1021/jm00097a001