6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde

Base Information

• Chemical Name: 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde
• CAS No.: 1460286-41-2
• Molecular Formula: C₁₇H₁₇N₃O₂
• Molecular Weight: 295.341
• Mol file: 1460286-41-2.mol

Synonyms:6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde

Chemical Property of 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde

There total 5 articles about 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-tert-butyl-phenyl)-2-hydroxymethyl-5H-pyrazolo[1,5-a]pyrazin-4-one (1460285-46-4) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde (1460286-41-2)

Guidance literature:

With Dess-Martin periodane; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;

Reference yield:

diethyl 1H-pyrazole-3,5-dicarboxylate (37687-24-4) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde (1460286-41-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 20 °C

2: ammonium acetate; acetic acid / 44 h / 110 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 18 h / 20 °C

With lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (1460286-38-7) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carbaldehyde (1460286-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate; acetic acid / 44 h / 110 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 18 h / 20 °C

With lithium aluminium tetrahydride; ammonium acetate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane;

upstream raw materials:

diethyl 1H-pyrazole-3,5-dicarboxylate

2-bromo-1-(4-(tert-butyl)phenyl)ethanone

1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

Downstream raw materials:

6-(4-tert-butyl-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one