2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

Base Information

• Chemical Name: 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER
• CAS No.: 269410-10-8
• Molecular Formula: C15H21 B O5
• Molecular Weight: 292.14
• Hs Code.: 2934999090
• Mol file: 269410-10-8.mol

Synonyms:2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

Chemical Property of 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

Chemical Property:

• Vapor Pressure: 7.33E-07mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 407.8°Cat760mmHg
• Flash Point: 200.5°C
• PSA: 53.99000
• Density: 1.11g/cm³
• LogP: 1.78100
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5-methoxycarbonylphenylboronic acid pinacol ester Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

There total 6 articles about 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-iodo-4-methoxy-benzoic acid methyl ester (35387-93-0) + bis(pinacol)diborane (73183-34-3) → methyl 4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (269410-10-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 20 - 90 ℃; for 16h;

DOI:10.1021/jm200553w

Reference yield: 70.0%

methyl 3-bromo-4-methoxybenzoate (35450-37-4) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → methyl 4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (269410-10-8)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); triethylamine; In 1,4-dioxane; for 6h; Inert atmosphere;

DOI:10.1002/ejoc.202100172

Reference yield: 64.0%

methyl 3-bromo-4-methoxybenzoate (35450-37-4) + bis(pinacol)diborane (73183-34-3) → methyl 4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (269410-10-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; for 18h; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2012.08.041

upstream raw materials:

3-iodo-4-methoxy-benzoic acid methyl ester

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

bis(pinacol)diborane

methyl 3-bromo-4-methoxybenzoate

Downstream raw materials:

dimethyl 6,6'-dimethoxybiphenyl-3,3'-dicarboxylate

methyl 2-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)acetate

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