N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide

Base Information

• Chemical Name: N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide
• CAS No.: 1570135-66-8
• Molecular Formula: C₁₉H₁₇N₃O₂
• Molecular Weight: 319.363
• Mol file: 1570135-66-8.mol

Synonyms:N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide

Chemical Property of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide

There total 3 articles about N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H14N2O2 → N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide (1570135-66-8)

Guidance literature:

C₁₉H₁₄N₂O₂; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

methyl derivative; In tetrahydrofuran; Cooling with ice;

DOI:10.1021/acs.orglett.7b03580

Reference yield:

1H-indole-3-carboxylic acid (771-50-6) + 2-(o-aminophenyl)oxazole (62882-10-4) → N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide (1570135-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride / 1 h / 50 °C

1.2: 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: Cooling with ice

With oxalyl dichloride; sodium hydride; In tetrahydrofuran;

DOI:10.1021/acs.orglett.7b03580

Reference yield:

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline (3416-93-1) + 3-chlorocarbonyl-1-methylindole (126921-19-5) → N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide (1570135-66-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1021/ja412880r

upstream raw materials:

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline

3-chlorocarbonyl-1-methylindole

1H-indole-3-carboxylic acid

2-(o-aminophenyl)oxazole

Downstream raw materials:

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-2-(4-methylphenylsulfonamido)-1H-indole-3-carboxamide