N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

Base Information

Chemical Name:N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine
CAS No.:1444176-47-9
Molecular Formula:C₂₀H₁₉Cl₂F₃N₂S
Molecular Weight:447.351
Hs Code.:

Synonyms:N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

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Chemical Property of N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

Chemical Property:

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Technology Process of N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

There total 5 articles about N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₁₆Cl₂F₃NO₃S₂

: 75-04-7,85404-22-4
ethylamine

: 1444176-47-9
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

Guidance literature:: In tetrahydrofuran; acetonitrile; at 20 - 25 ℃;

Reference yield:

: 1444174-23-5
C₁₉H₁₄Cl₂F₃NO₂S

: 1444176-47-9
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

1.2: 2 h / 20 - 25 °C

2.1: triethylamine / dichloromethane / 20 - 25 °C

3.1: tetrahydrofuran; acetonitrile / 20 - 25 °C

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 943437-03-4
1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1444176-47-9
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; hydrogen sulfide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine; hydroxylamine-O-sulfonic acid / dichloromethane; water / 0.75 h / -15 - 0 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; sodium acetate / tetrahydrofuran / 13 h / 80 °C / 3750.38 - 5625.56 Torr / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

4.2: 2 h / 20 - 25 °C

5.1: triethylamine / dichloromethane / 20 - 25 °C

6.1: tetrahydrofuran; acetonitrile / 20 - 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen sulfide; sodium acetate; palladium diacetate; diisobutylaluminium hydride; triethylamine; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;