N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

Base Information

Chemical Name:N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide
CAS No.:1444176-48-0
Molecular Formula:C₂₄H₂₅Cl₂F₃N₂OS₂
Molecular Weight:549.509
Hs Code.:

Synonyms:N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

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Chemical Property of N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

Chemical Property:

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Technology Process of N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

There total 7 articles about N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 627-04-3
S-ethylthioglycolic acid

: 1444176-47-9
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]ethanamine

: 1444176-48-0
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 - 25 ℃; for 16h;

Reference yield:

: 1427274-60-9
1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butan-1-one

: 1444176-48-0
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; hydroxylamine-O-sulfonic acid / dichloromethane; water / 0.75 h / -15 - 0 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; sodium acetate / tetrahydrofuran / 13 h / 80 °C / 3750.38 - 5625.56 Torr / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

3.2: 2 h / 20 - 25 °C

4.1: triethylamine / dichloromethane / 20 - 25 °C

5.1: tetrahydrofuran; acetonitrile / 20 - 25 °C

6.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 - 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium acetate; palladium diacetate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1444176-97-9
[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

: 1444176-48-0
N-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methyl]-N-ethyl-2-ethylsulfanylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 - 25 °C

2: tetrahydrofuran; acetonitrile / 20 - 25 °C

3: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 - 25 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane; acetonitrile;