(R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate

Base Information

• Chemical Name: (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate
• CAS No.: 1432059-42-1
• Molecular Formula: C₂₃H₂₁Cl₂N₃O₃
• Molecular Weight: 458.344
• Mol file: 1432059-42-1.mol

Synonyms:(R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate

Chemical Property of (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate

There total 10 articles about (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylsilyl cyanide (7677-24-9) + (E)-tert-butyl {1-[(E)-3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-ylidene}carbamate → (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate (1432059-42-1)

Guidance literature:

With quinine thiourea; isopropyl alcohol; In 1,2-dichloro-ethane; at -25 ℃; for 16h; enantioselective reaction;

DOI:10.1002/adsc.201200630

Reference yield: 90.0%

trimethylsilyl cyanide (7677-24-9) + C22H20Cl2N2O3 (1432059-19-2) → (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate (1432059-42-1)

Guidance literature:

With C₂₈H₂₆F₆N₄S; 1,1,1,3',3',3'-hexafluoro-propanol; In dichloromethane; at -70 ℃; for 48h; enantioselective reaction;

DOI:10.1039/c2cc36665g

Reference yield:

trimethylsilyl cyanide (7677-24-9) + C22H20Cl2N2O3 (1432059-19-2) → (R,E)-tert-butyl {3-cyano-1-[3-(3,4-dichlorophenyl)allyl]-2-oxoindolin-3-yl}carbamate (1432059-42-1) + tert-butyl (E)-(3-cyano-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindolin-3-yl)carbamate (1432059-82-9)

Guidance literature:

With C₂₈H₂₆F₆N₄S; 1,1,1,3',3',3'-hexafluoro-propanol; Triphenylphosphine oxide; In 1,2-dichloro-ethane; at -30 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c2cc36665g

upstream raw materials:

trimethylsilyl cyanide

C₂₂H₂₀Cl₂N₂O₃

3,4-dichlorobenzaldehyde

ethyl (E)-3-(3,4-dichloro-phenyl)-2-propenoate