1432059-82-9

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 1432059-19-2 C₂₂H₂₀Cl₂N₂O₃ 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 40950-94-5 ethyl (E)-3-(3,4-dichloro-phenyl)-2-propenoate 
• 148775-22-8 3-(3,4-dichlorophenyl)-prop-2-en-1-ol 
• 149946-25-8 (E)-4-(3-bromoprop-1-en-1-yl)-1,2-dichlorobenzene 
• 945736-71-0 (E)-1-(3-(3,4-dichlorophenyl)allyl)indoline-2,3-dione 
• 68014-21-1 triphenyl(t-butoxycarbonylimino)phosphorane 

Downstream Products

• 1432059-83-0 (S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile 

Relevant academic research and scientific papers

Catalytic Asymmetric Addition Reactions of Formaldehyde N, N-Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives

A number of nitrile-containing chiral molecules were synthesized via asymmetric nucleophilic addition of formaldehyde N,N-dialkylhydrazone as the nitrile equivalent. Chiral N,N′-dioxide/metal salt complexes enabled the asymmetric addition reactions to both isatin-derived imines and α,β-unsaturated ketones, generating amino nitriles and 4-oxobutanenitrile derivatives in good yields with high enantioselectivities. This protocol was highlighted by avoiding the use of toxic nitrile reagents, wide substrate scope, and versatile transformations of chiral hydrazone adducts into other valuable molecules.

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.