dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate

Base Information

• Chemical Name: dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate
• CAS No.: 173776-65-3
• Molecular Formula: C₁₄H₁₆O₇S
• Molecular Weight: 328.343
• Mol file: 173776-65-3.mol

Synonyms:dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate

Chemical Property of dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate

There total 5 articles about dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

malonic acid dimethyl ester (108-59-8) + 2-bromo-1-(4-methanesulfonylphenyl)ethanone (50413-24-6) → dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate (173776-65-3) + 2,2-bis-[2-(4-methanesulfonyl-phenyl)-2-oxo-ethyl]-malonic acid dimethyl ester

Guidance literature:

With potassium carbonate; In acetone; at 40 - 45 ℃; for 1h;

DOI:10.1016/S0040-4020(99)00274-4

Reference yield: 63.3%

malonic acid dimethyl ester (108-59-8) + 2-bromo-1-(4-methanesulfonylphenyl)ethanone (50413-24-6) → dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate (173776-65-3)

Guidance literature:

With potassium carbonate; potassium iodide; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1021/jm950664x

Reference yield:

4-(Methylthio)acetophenone (1778-09-2) → dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate (173776-65-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / mCPBA / CH₂Cl₂ / Ambient temperature

2: 15.7 g / HCl, bromine / acetic acid

3: 63.3 percent / K₂CO₃, KI / tetrahydrofuran / 6 h / Ambient temperature

With hydrogenchloride; bromine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; dichloromethane; acetic acid;

DOI:10.1021/jm950664x

upstream raw materials:

malonic acid dimethyl ester

2-bromo-1-(4-methanesulfonylphenyl)ethanone

4-(Methylthio)acetophenone

4-(methanesulfonyl)acetophenone

Downstream raw materials:

2-[2-(4-Methanesulfonyl-phenyl)-2-oxo-ethyl]-2-[2-oxo-2-(4-trifluoromethyl-phenyl)-ethyl]-malonic acid dimethyl ester

2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one

methyl-3-(3',5'-difluorophenyl)-1-(methoxycarbonyl)-4-(4'-(methylsulfonyl)phenyl)-2-oxocyclopent-3-enecarboxylate

C₃₅H₃₃F₃O₉S₃