(2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

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Chemical Name:(2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol
CAS No.:1291093-80-5
Molecular Formula:C₂₃H₂₈ClNO₇
Molecular Weight:465.931
Hs Code.:

Synonyms:(2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

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Chemical Property of (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

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Technology Process of (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

There total 4 articles about (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1291093-79-2
7-(5-bromo-2-chloro-benzyl)-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine

: 32469-28-6,55515-28-1,55515-29-2,32384-65-9
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

: 1291093-80-5
(2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

Guidance literature:: 7-(5-bromo-2-chloro-benzyl)-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 1h;

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; toluene; at -78 ℃;

methanol;

Reference yield:

: 5466-88-6
3,4-dihydro-3-oxo-2H-1,4-benzoxazine

: 1291093-80-5
(2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C

1.2: 3 h

2.1: borane-THF / tetrahydrofuran / 6 h / 20 °C / Reflux

3.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

4.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile; 1,2-dichloro-ethane / 20 - 50 °C

5.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C

5.2: -78 °C

With triethylsilane; aluminum (III) chloride; n-butyllithium; borane-THF; boron trifluoride diethyl etherate; potassium tert-butylate; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 77901-22-5
4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 1291093-80-5
(2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylmethyl)-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile; 1,2-dichloro-ethane / 20 - 50 °C

3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C

3.2: -78 °C

With triethylsilane; aluminum (III) chloride; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;