N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

Base Information

Chemical Name:N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide
CAS No.:257603-52-4
Molecular Formula:C₂₆H₄₂N₂O₄Si
Molecular Weight:474.716
Hs Code.:

Synonyms:N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

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Chemical Property of N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

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Technology Process of N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

There total 4 articles about N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 257603-51-3
N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

: 74-88-4
methyl iodide

: 257603-52-4
N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 20 ℃; for 19h;
DOI:10.1016/S0968-0896(99)00177-7

Reference yield:

: 185030-05-1
N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-hydroxy-2-phenylacetamide

: 257603-52-4
N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: 26 percent / NaH; n-Bu₄NI / tetrahydrofuran / 19 h / 20 °C

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Substitution / 2: Methylation;
DOI:10.1016/S0968-0896(99)00177-7

Reference yield:

: 1460-47-5
2-cyclobutyl-2-hydroxy-2-phenylacetic acid

: 257603-52-4
N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / 1-HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CHCl₃ / 15 h / 20 °C

2: 96 percent / imidazole / dimethylformamide / 18 h / 20 °C

3: 26 percent / NaH; n-Bu₄NI / tetrahydrofuran / 19 h / 20 °C

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Substitution / 3: Methylation;
DOI:10.1016/S0968-0896(99)00177-7