(S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Base Information

Chemical Name:(S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one
CAS No.:1619968-89-6
Molecular Formula:C₂₇H₂₈FN₅O₂
Molecular Weight:473.55
Hs Code.:

Synonyms:(S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Suppliers and Price of (S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

There total 9 articles about (S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375108-41-0
7-bromo-3-methylquinoline

: 1619968-97-6
(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

: 1619968-89-6
(S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: (S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 100 ℃; for 1h;

7-bromo-3-methylquinoline; With potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h;

Reference yield:

: 204688-61-9
2‐[(3S)‐1‐[(tert‐butoxy)carbonyl]pyrrolidin‐3‐yl]acetic acid

: 1619968-89-6
(S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / diethyl ether / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.1: hydrazine hydrate / ethanol / 80 °C / Inert atmosphere

5.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / propan-1-ol; water / 16 h / 140 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

8.1: potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / 100 °C

8.2: 1 h / 100 °C

With hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; potassium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bis(pinacol)diborane; In 1,4-dioxane; propan-1-ol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1619968-93-2
ethyl [(3S)-1-propanoyl-3-pyrrolidinyl]acetate

: 1619968-89-6
(S)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidinyl)methyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / ethanol / 80 °C / Inert atmosphere

2.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / propan-1-ol; water / 16 h / 140 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

5.1: potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / 100 °C

5.2: 1 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; potassium carbonate; hydrazine hydrate; bis(pinacol)diborane; In 1,4-dioxane; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;