(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

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Chemical Name:(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one
CAS No.:1619968-97-6
Molecular Formula:C₁₇H₂₀BrFN₄O₂
Molecular Weight:411.274
Hs Code.:

Synonyms:(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

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Chemical Property of (S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

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Technology Process of (S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

There total 8 articles about (S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332333-90-0
4-(4-bromo-2-fluorophenyl)-5-{[(3S)-1-propanoyl-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one

: 74-88-4
methyl iodide

: 1619968-97-6
(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 204688-61-9
2‐[(3S)‐1‐[(tert‐butoxy)carbonyl]pyrrolidin‐3‐yl]acetic acid

: 1619968-97-6
(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / diethyl ether / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4: hydrazine hydrate / ethanol / 80 °C / Inert atmosphere

5: dichloromethane / 2 h / 20 °C / Inert atmosphere

6: potassium carbonate / propan-1-ol; water / 16 h / 140 °C / Inert atmosphere

7: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; sodium hydride; potassium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; propan-1-ol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1619968-93-2
ethyl [(3S)-1-propanoyl-3-pyrrolidinyl]acetate

: 1619968-97-6
(S)-4-(4-bromo-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1 H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 80 °C / Inert atmosphere

2: dichloromethane / 2 h / 20 °C / Inert atmosphere

3: potassium carbonate / propan-1-ol; water / 16 h / 140 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; hydrazine hydrate; In propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;