4-(2-MORPHOLIN-4-YL-ETHYL)-ANILINE

Base Information

• Chemical Name: 4-(2-MORPHOLIN-4-YL-ETHYL)-ANILINE
• CAS No.: 262368-47-8
• Molecular Formula: C12H18 N2 O
• Molecular Weight: 206.288
• Hs Code.: 2934999090
• Mol file: 262368-47-8.mol

Synonyms:4-(2-(Morpholin-4-yl)ethyl)phenylamine;4-(2-Morpholinoethyl)aniline; 4-(2-Morpholinoethyl)phenylamine; 4-[2-(4-Morpholinyl)ethyl]aniline

Chemical Property of 4-(2-MORPHOLIN-4-YL-ETHYL)-ANILINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 80.5-81.5℃
• Refractive Index: 1.566
• Boiling Point: 343.596°C at 760 mmHg
• PKA: 7.43±0.10(Predicted)
• Flash Point: 161.602°C
• PSA: 38.49000
• Density: 1.091g/cm³
• LogP: 1.66260
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Morpholinoethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-MORPHOLIN-4-YL-ETHYL)-ANILINE

There total 9 articles about 4-(2-MORPHOLIN-4-YL-ETHYL)-ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-[2-(4-nitro-phenyl)-ethyl]-morpholine (210158-20-6) → 4-[2-(4-morpholinyl)ethyl]aniline (262368-47-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 72h; under 750.075 Torr;

DOI:10.1002/anie.201205475 DOI:10.1002/anie.201205475

Reference yield: 100.0%

→ 4-[2-(4-morpholinyl)ethyl]aniline (262368-47-8)

Guidance literature:

Reference yield:

(4-nitrophenyl)ethyl bromide (5339-26-4) → 4-[2-(4-morpholinyl)ethyl]aniline (262368-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 16 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 72 h / 750.08 Torr

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/anie.201205475 DOI:10.1002/anie.201205475

upstream raw materials:

4-[2-(4-nitro-phenyl)-ethyl]-morpholine

morpholine

4-nitrobenzeneacetic acid

sodium hydrogencarbonate

Downstream raw materials:

4-(2-morpholin-4-ylethyl)benzeneisothiocyanate

C₂₃H₃₆N₄O₅

C₃₆H₃₁F₂N₇O₂

2,6-diisopropyl-4-((4-(2-morpholinoethyl)phenyl)diazenyl)phenol

Refernces

• 1、 -. "Heterocyclic compound". Paragraph 0185; 0187. . Retrieved 2017/09/28.
• 2、 -. "8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER". Paragraph 00600. . Retrieved 2013/04/10.