210158-20-6

Basic information

• Product Name: 4-(4-nitrophenethyl) morpholine
• Synonyms: 4-(4-nitrophenethyl) morpholine;4-[2-(4-NITROPHENYL)ETHYL]MORPHOLINE(WXG03405)
• CAS NO: 210158-20-6
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.26704
• Mol File: 210158-20-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-nitrophenethyl) morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-nitrophenethyl) morpholine(210158-20-6)
• EPA Substance Registry System: 4-(4-nitrophenethyl) morpholine(210158-20-6)

Safety Data

• Hazardous Substances Data: 210158-20-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 1460-05-5 p-nitrophenylacetaldehyde 
• 100-13-0 4-nitrostyrene 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 555-16-8 4-nitrobenzaldehdye 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 20020-28-4 <(p-Nitrophenyl)ethyl>-β-sulfonic ester 
• 50508-40-2 1-morpholino-2-(4-nitrophenyl)ethanone 
• 6948-72-7 4-[2-p-toluenesulphonyloxy ethyl]nitrobenzene 
• 20264-95-3 2-(4-nitrophenyl)ethyl chloride 

Downstream Products

• 1370447-65-6 4-[2-(4-hydrazinylphenyl)ethyl]morpholine 
• 1370447-66-7 2-(3-fluorophenyl)(2-{4-[2-(morpholin-4-yl)ethyl]phenyl}hydrazinylidene)ethanoic acid 
• 1370447-69-0 5-(3-fluorophenyl)-2-{4-[2-(morpholin-4-yl)ethyl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1370446-52-8 2-[3-(3-fluorophenyl)-1-{4-[2-(morpholin-4-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide 
• 954424-92-1 2-(4,4-dimethyl-cyclohex-1-enyl)-4-(2-morpholin-4-yl-ethyl)-phenylamine 
• 954424-64-7 2-cyclohex-1-enyl-4-(2-morpholin-4-yl-ethyl)-phenylamine 
• 954424-63-6 2-bromo-4-(2-morpholin-4-yl-ethyl)-phenylamine 
• 1416371-71-5 2,6-diisopropyl-4-((4-(2-morpholinoethyl)phenyl)diazenyl)phenol 
• 262368-47-8 4-[2-(4-morpholinyl)ethyl]aniline 

Relevant articles and documents

HETEROCYCLIC COMPOUND

The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.

Nucleophilic additions to polarized vinylarenes

The addition of nucleophiles to the terminal double bond carbon of a styrene incorporating an electron-withdrawing group at the ortho or para position has been studied. The conditions for this transformation have been optimized and structural modifications to the substrate have been explored. The structural changes included variation of the activating group on the aromatic ring and positioning substituents on the side chain double bond. The study revealed that nitro substitution gave the best results for addition of carbon and nitrogen nucleophiles. Cyano-substituted systems added carbon nucleophiles, but underwent polymerization or degradation with nitrogen nucleophiles. Ethoxycarbonyl-bearing substrates reacted primarily at the ester carbonyl. The reaction generally proceeded well with methyl on the α carbon of the double bond, but was slowed by methyl at the β position. The yields varied from 50% to 97% for 22 examples.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.