1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

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Chemical Name:1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one
CAS No.:641640-04-2
Molecular Formula:C₂₆H₄₀N₂O₃SSi
Molecular Weight:488.767
Hs Code.:

Synonyms:1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

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Chemical Property of 1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

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Technology Process of 1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

There total 5 articles about 1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 641640-03-1
1-[1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl]-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

: 641640-04-2
1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

Guidance literature:: With magnesium monoperoxyphthalate hexahydrate; In methanol; dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm030276s

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 641640-04-2
1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2.1: 85 percent / methanol / 70 °C

3.1: trimethylaluminum / hexane; CH₂Cl₂ / 0 - 20 °C

3.2: 93 percent / hexane; CH₂Cl₂ / 20 °C

4.1: 48 percent / tetrahydrofuran / 0 - 20 °C

5.1: 45 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH₂Cl₂ / 1 h / 20 °C

With trimethylaluminum; sodium methylate; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/jm030276s

Reference yield:

: 346684-15-9
methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

: 641640-04-2
1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / methanol / 70 °C

2.1: trimethylaluminum / hexane; CH₂Cl₂ / 0 - 20 °C

2.2: 93 percent / hexane; CH₂Cl₂ / 20 °C

3.1: 48 percent / tetrahydrofuran / 0 - 20 °C

4.1: 45 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH₂Cl₂ / 1 h / 20 °C

With trimethylaluminum; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm030276s