ETHYL 5-METHOXY-1H-PYRROLO[2, 3-C]PYRIDINE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 5-METHOXY-1H-PYRROLO[2, 3-C]PYRIDINE-2-CARBOXYLATE
• CAS No.: 3469-63-4
• Molecular Formula: C11H12 N2 O3
• Molecular Weight: 220.228
• Hs Code.: 2933990090
• Mol file: 3469-63-4.mol

Synonyms:5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylicacid ethyl ester

Chemical Property of ETHYL 5-METHOXY-1H-PYRROLO[2, 3-C]PYRIDINE-2-CARBOXYLATE

Chemical Property:

• Melting Point: 103-106℃
• Boiling Point: 384.4±37.0 °C(Predicted)
• PKA: 12.38±0.40(Predicted)
• PSA: 64.21000
• Density: 1.269
• LogP: 1.74820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 5-METHOXY-1H-PYRROLO[2, 3-C]PYRIDINE-2-CARBOXYLATE

There total 4 articles about ETHYL 5-METHOXY-1H-PYRROLO[2, 3-C]PYRIDINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 3-(2-methoxy-5-nitropyridin-4-yl)-2-oxopropanoate (3469-62-3) → 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester (3469-63-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

DOI:10.3390/molecules190913342

Reference yield:

2-chloro-4-methyl-5-nitro-pyridine (23056-33-9) → 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester (3469-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 5 h / Reflux

2.1: potassium tert-butylate / diethyl ether; ethanol / 0.25 h

2.2: Reflux

2.3: 2 h / 20 °C

3.1: hydrogen / palladium on carbon / ethanol / 24 h

With potassium tert-butylate; hydrogen; palladium on carbon; In methanol; diethyl ether; ethanol;

Reference yield:

2-Methoxy-4-methyl-5-nitropyridine (6635-90-1) → 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester (3469-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / diethyl ether; ethanol / 0.25 h

1.2: Reflux

1.3: 2 h / 20 °C

2.1: hydrogen / palladium on carbon / ethanol / 24 h

With potassium tert-butylate; hydrogen; palladium on carbon; In diethyl ether; ethanol;

upstream raw materials:

2-Methoxy-4-methyl-5-nitropyridine

2-chloro-4-methyl-5-nitro-pyridine

ethyl 3-(2-methoxy-5-nitropyridin-4-yl)-2-oxopropanoate

Downstream raw materials:

2-Benzyl-8-methoxy-2,3,10,10a-tetrahydropyrido[4',3':4,5]pyrrolo[1,2-a]-pyrazine-1,4-dione

Methyl 2-benzyl-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]-pyrazine-8-carboxylate

Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide

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