4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran

Base Information

• Chemical Name: 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran
• CAS No.: 144735-68-2
• Molecular Formula: C₂₅H₂₆O₈
• Molecular Weight: 454.477

Synonyms:4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran

Chemical Property of 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran

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Technology Process of 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran

There total 10 articles about 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

acetic anhydride (108-24-7) + 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane (144735-57-9) → 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran (144735-68-2)

Guidance literature:

With phosphoric acid; acetic acid; at 100 ℃; for 2h;

DOI:10.1021/jo00052a046

Reference yield:

4-benzyloxy-3-methoxyacetophenone (1835-11-6) → 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran (144735-68-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 63 percent / POCl₃ / 1) 0 deg C, 20 min, 2) 65 deg C, 10 h

2: 79 percent / NaOH / H₂O; dioxane / 2 h / 80 °C

3: 1) CuSO₄*H₂O, NH₄OH, NH₂OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h

4: 92 percent / H₂ / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature

5: 82 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

6: 64 percent / gl. HOAc, 85percent H₃PO₄ / 2 h / 100 °C

With pyridine; ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; phosphoric acid; hydroxylamine hydrochloride; hydrogen; copper(II) sulfate; acetic acid; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/jo00052a046

Reference yield:

vanillin (121-33-5,8014-42-4) → 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran (144735-68-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 82 percent / Br₂, HOAc / 1 h / Ambient temperature

2: 98 percent / pyrrolidine / pyridine / 6 h / 100 °C

3: 1) CuSO₄*H₂O, NH₄OH, NH₂OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h

4: 92 percent / H₂ / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature

5: 82 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

6: 64 percent / gl. HOAc, 85percent H₃PO₄ / 2 h / 100 °C

With pyrrolidine; pyridine; ammonium hydroxide; lithium aluminium tetrahydride; phosphoric acid; hydroxylamine hydrochloride; hydrogen; bromine; copper(II) sulfate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine;

DOI:10.1021/jo00052a046

upstream raw materials:

acetic anhydride

2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane

4-benzyloxy-3-methoxyacetophenone

vanillin

Downstream raw materials:

3-acetyl-5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran

4-acetyl-5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran

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