methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

Base Information

Chemical Name:methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate
CAS No.:1327278-03-4
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:

Synonyms:methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

Chemical Property:

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Technology Process of methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

There total 4 articles about methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1327277-98-4
(S)-methyl 5-((2-hydroxy-1-phenylethyl)amino)-3,3-dimethyl-5-oxopentanoate

: 1327278-03-4
methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

Guidance literature:: (S)-methyl 5-((2-hydroxy-1-phenylethyl)amino)-3,3-dimethyl-5-oxopentanoate; With trichlorophosphate; In toluene; at 20 ℃; for 2h;

With water; potassium carbonate; In dichloromethane; for 0.75h;
DOI:10.1002/asia.201100452

Reference yield:

: 4160-82-1
3,3-dimethylglutaric anhydride

: 1327278-03-4
methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane; toluene / 5.5 h / 20 - 60 °C

2.1: methanol; diethyl ether / 0 - 20 °C

3.1: trichlorophosphate / toluene / 2 h / 20 °C

3.2: 0.75 h

With trichlorophosphate; In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1002/asia.201100452

Reference yield:

: 1327278-20-5
3-(((S)-2-hydroxy-1-phenylethyl-carbamoyl)methyl)-3-methylbutanoic acid

: 1327278-03-4
methyl 3-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; diethyl ether / 0 - 20 °C

2.1: trichlorophosphate / toluene / 2 h / 20 °C

2.2: 0.75 h

With trichlorophosphate; In methanol; diethyl ether; toluene;
DOI:10.1002/asia.201100452