39604-68-7

Usage

Preparation

Preparation by partial methylation of 2,4,6-tri-hydroxyphenyl 4-methoxybenzyl ketone, ? with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone, for 3 h (64%); ? with diazomethane in ethyl ether at 0° (80%) or in methanol; ? with methyl iodide in the presence of potassium carbonate in refluxing acetone for 3 h (42%).

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 104-47-2 p-methoxybenzylnitrile 
• 15485-66-2 2,4,6-trihydroxy-4'-methoxydeoxybenzoin 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 64818-77-5 (+/-)-3-hydroxy-4,6-dimethoxy-3-(p-methoxybenzyl)benzofuran-2(3H)-one 
• 15485-65-1 2,4,4',6-tetrahydroxydeoxybenzoin 
• 186581-53-3 diazomethane 
• 104-01-8 4-Methoxyphenylacetic acid 
• 621-23-8 1,2,3-trimethoxybenzene 
• 1162-82-9 4',5,7-trimethoxyisoflavone 
• 50-00-0 formaldehyd 
• 39604-66-5 2-hydroxy-4,6-dimethoxyphenyl benzyl ketone 
• 117828-32-7 4,6-dihydroxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 

Downstream Products

• 787637-49-4 2,4,6,4'-tetramethoxy-deoxybenzoin 
• 54321-18-5 5,7-dimethoxy-3-(4-methoxy-phenyl)-2-methyl-chromen-4-one 
• 102019-20-5 6,8-dimethoxy-4-(4-methoxy-phenyl)-3,4-dihydro-benz[b]oxepin-2,5-dione 
• 14736-59-5 4-hydroxy-5,7-dimethoxy-3-(4-methoxyphenyl)-1-benzopyran-2-one 
• 1162-82-9 4',5,7-trimethoxyisoflavone 
• 21554-70-1 4',5,7-trimethoxyisoflavanone 
• 96682-32-5 2-hydroxy-4,6-dimethoxyphenyl α-hydroxymethyl-4-methoxybenzyl ketone 
• 28750-74-5 1-(3-Bromo-2-hydroxy-4,6-dimethoxy-phenyl)-2-(4-methoxy-phenyl)-ethanone 
• 218899-18-4 Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester 
• 218899-20-8 Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester methyl ester 
• 218899-23-1 Nonanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester methyl ester 
• 218899-27-5 Decanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester methyl ester 
• 218899-26-4 Nonanedioic acid butyl ester 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester 
• 218899-30-0 Decanedioic acid butyl ester 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester 

Relevant academic research and scientific papers

Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein

A series of deoxybenzoin derivatives from genistein were synthesized and their structures were elucidated by 1H NMR, mass spectral data and micro analyses. The structures of 2, 7 and 10 were determined by single-crystal X-ray analysis. These obtained compounds were evaluated for their assayed antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Most compounds have displayed comparable antibacterial activity against bacterial. On the basis of the biological results, structure-activity relationships are discussed.

Syntheses of novel hapten-protein conjugates for production of highly specific antibodies to formononetin, daidzein and genistein

The syntheses of novel hapten-carrier protein conjugates are described. Isoflavones functionalised in C2 were coupled to bovine serum albumin or swine thyroglobulin. The antibodies obtained were used for the development of ELISAs (enzyme-linked immunosorb

A facile synthesis of 2-substituted isoflavones for immunoassay: Assembly of the isoflavonoid skeleton by means of a novel cyclisation reaction

For the purpose of the development of immunoassays for wide-scale screening, isoflavones suitable for attachment to a hapten were prepared. A new cyclisation reaction allowed the direct conversion of 2- (acyloxy)deoxybenzoins to 2-alkylisoflavones by treatment with chlorotrimethylsilane and triethylamine in dimethylformamide.

Hydroxymethylation Studies of o-Hydroxyphenyl Benzyl Ketones with and without the use of Phase Transfer Catalyst: A Novel Synthesis of Isoflavanones

o-Hydroxyphenyl benzyl ketones, having a resorcinol unit in ring-A, on treatment with formalin in chloroform-aq. potassium carbonate biphase system give the corresponding α-hydroxymethyl derivatives.This reaction when carried out in the presence of a phas

A Novel Photochemical Structural Inversion: The First Methoxy-Hydroxymethyl Isomerization

Photolysis of 4-methoxybenzofuran-3(2H)-ones provides the first example of structural inversion of an arylmethoxy-group to the corresponding hydroxymethyl function.Suitable structural parameters permit subsequent rearrangement of the heterocyclic ring to 5-hydroxyisochroman-4-ones.By contrast photolysis of the isomeric 4-methoxybenzofuran-2(3H)-one leads directly to the deoxybenzoin analogue.