cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

Base Information

Chemical Name:cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate
CAS No.:1357001-70-7
Molecular Formula:CH₄O₃S*C₃₂H₃₃F₂N₃O
Molecular Weight:609.737
Hs Code.:

cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

Synonyms:cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

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Chemical Property of cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

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Technology Process of cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

There total 3 articles about cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 1357001-59-2
AMN-2cis

: 459-04-1
4-Fluorophenylacetyl chloride

: 1357001-70-7
cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

Guidance literature:: AMN-2cis; 4-Fluorophenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 130 ℃; for 0.166667h; Microwave irradiation;

With sodium carbonate; In dichloromethane;

methanesulfonic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1002916-54-2
[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride

: 1357001-70-7
cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: methanol / 24 h / Inert atmosphere

2.2: 2 h / 20 °C

2.3: pH 11

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 130 °C / Microwave irradiation

3.3: 20 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

: 863514-54-9
4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

: 1357001-70-7
cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluoro-phenyl)-2'-(4-fluorobenzyl)-carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 24 h / Inert atmosphere

1.2: 2 h / 20 °C

1.3: pH 11

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 130 °C / Microwave irradiation

2.3: 20 °C

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;