(E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate
CAS No.:1375957-49-5
Molecular Formula:C₃₇H₂₈N₂O₆S
Molecular Weight:628.705
Hs Code.:

Synonyms:(E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

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Chemical Property of (E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

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Technology Process of (E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

There total 6 articles about (E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1375957-32-6
4-(3-(4-acetylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl-4-methylbenzenesulfonate

: 123-11-5
4-methoxy-benzaldehyde

: 1375957-49-5
(E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 3h;
DOI:10.1007/s00044-012-0079-x

Reference yield:

: 64675-83-8
4-(toluene-4-sulfonyloxy)-benzoyl chloride

: 1375957-49-5
(E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1.08 h / 20 °C

2: acetic acid / 8 h / Reflux

3: sodium hydroxide / ethanol / 3 h / 20 °C

With pyridine; acetic acid; sodium hydroxide; In ethanol;
DOI:10.1007/s00044-012-0079-x

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1375957-49-5
(E)-4-(3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl) phenyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: pyridine / 1.08 h / 20 °C

3: acetic acid / 8 h / Reflux

4: sodium hydroxide / ethanol / 3 h / 20 °C

With pyridine; thionyl chloride; acetic acid; sodium hydroxide; In ethanol;
DOI:10.1007/s00044-012-0079-x