Technology Process of (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-N-(11-(4-fluorophenyl)undecanoyl)-2-amino-1,3,4-octadecanetriol
There total 11 articles about (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-N-(11-(4-fluorophenyl)undecanoyl)-2-amino-1,3,4-octadecanetriol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1.1: potassium carbonate; copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 20 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 0 °C / Inert atmosphere
3.1: 2,6-di-tert-butyl-4-methylpyridine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Molecular sieve
3.2: -10 °C / Inert atmosphere; Molecular sieve
4.1: hydrogen / ethyl acetate
5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere
6.1: potassium hydroxide / methanol / 20 °C / Inert atmosphere
7.1: 10 wt% Pd(OH)2 on carbon; hydrogen / chloroform; methanol / 17 h / 20 °C
With
pyridine; 2,6-di-tert-butyl-4-methylpyridine; copper(ll) sulfate pentahydrate; triflic azide; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2018.11.005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere
2: potassium hydroxide / methanol / 20 °C / Inert atmosphere
3: 10 wt% Pd(OH)2 on carbon; hydrogen / chloroform; methanol / 17 h / 20 °C
With
10 wt% Pd(OH)2 on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2018.11.005
