914824-72-9

Upstream product

• 26305-13-5 5,6-dimethyl-2,4-dihydroxy pyrimidine 
• 6972-79-8 dibenzyl glycerol 
• 1780-32-1 2,4-dichloro-5,6-dimethylpyrimidine 
• 26305-13-5 5,6-dimethyluracil 
• 120129-83-1 2,4-dimethoxy-5,6-dimethylpyrimidine 
• 5781-53-3 monomethyl oxalyl chloride 
• 139871-31-1 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxy-5-methylpyrimidine 
• 77356-14-0 1,3-dibenzyloxy-2-propanone 

Downstream Products

• 1278985-06-0 6-[(3-benzyloxy-2-benzyIoxymethyl)prop-1-enyl]-1,5-dimethyl-4-methoxy-pyrimidin-2-one 
• 1329426-95-0 (Z)-6-[2-(p-anisyldiphenylmethoxy)methyl-3-hydroxypropenyl]-1,5-dimethylpyrimidin-2,4-dione 
• 1311145-61-5 6-[3-hydroxy-2-(4-methoxytriphenylmethoxymethyl)propyl]-1-methoxymethyl-5-methylpyrimidin-2,4-dione 
• 1311145-64-8 C₄₉H₄₆N₂O₆ 
• 1311145-52-4 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione 
• 914824-82-1 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine 
• 1311145-51-3 6-[3-(benzyloxy)-2-(benzyloxymethyl)propyl]-5-methylpyrimidine-2,4-dione 
• 1311145-60-4 C₃₃H₃₈N₂O₇ 
• 1311145-59-1 C₅₃H₅₄N₂O₈ 
• 1311145-53-5 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1-methoxymethyl-5-methylpyrimidine-2,4-dione 
• 1311145-55-7 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-3-methoxymethyl-5-methylpyrimidine-2,4-dione 
• 1312992-32-7 6-[3-(benzyloxy)-2-(benzyloxymethyl)propyl]-4-methoxy-1,5-dimethylpyrimidin-2(1H)-one 

Relevant academic research and scientific papers

Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives

A series of novel N-alkylated C-6-isobutyl- or -propyl pyrimidine derivatives were synthesized and their antiproliferative effect was evaluated on a panel of tumor cell lines including leukemia cell line K562 and normal diploid human fibroblasts. N-methox

NEW 6-SUBSTITUTED PYRIMIDINE DERIVATIVES

The Invention deals with new 6-substituted pyrimidine derivatives of the general formula (I): where: R1 = methyl or H or CH2X, X = Br, F, Cl R2 = oxygen or methoxy or OH R3 = oxygen or methoxy or OH R4 = H or methyl or (CH2)nY, n = 2 or 3, Y = OH or Br or F or Cl or OCOCH3, R5 = (II), (III), R6 and R7 can independently of each other be H, CH2Z, CH2OH, CH2OCH2Ph, CH2OCPh2PhOCH3; Z=Br, F, Cl; Where, if R5 = (IV) and if one of R6 and R7 CH2Z (Z = Br, F, Cl), then R5 and R1 form with CH2A, A = Cl, Br, F a substituted unsaturated 5-membered ring and, provided that R6 or R7 = H, then the other of them cannot be H; and R8, R9, R10 = OH, CH2OCH2Ph, H, OC2O3CH3, CH2OH, CH2OCPh2PhOCH3, CH2OSO2PhCH3; and where F, regardless of which place it may take in the molecule, may appear in the form of radioisotope 18F; one of the carbons occupying any place in the compound of the general formula I may appear in the form of radioisotope 11C, just as an oxygen occupying any place in the compound of the general formula I may appear in the form of radioisotope 15O; the Invention also deals with their use as substrates in the Positron Emission Tomography (PET), as well as their use in tumor therapy. Formulae (I), (II), (III), (IV)

Methoxymethyl (MOM) group nitrogen protection of pyrimidines bearing C-6 acyclic side-chains

Novel N-methoxymethylated (MOM) pyrimidine (4-13) and pyrimidine-2,4- diones (15-17) nucleoside mimetics in which an isobutyl side-chain is attached at the C-6 position of the pyrimidine moiety were synthesized. Synthetic methods via O-persilylated or N-a

Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: New lead structures for monitoring gene expression in vivo

Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is