914824-72-9Relevant articles and documents
Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives
Gazivoda Kraljevi?, Tatjana,Ili?, Nata?a,Stepani?, Vi?nja,Sappe, Lana,Petranovi?, Jasna,Kraljevi? Paveli?, Sandra,Rai?-Mali?, Silvana
supporting information, p. 2913 - 2917 (2014/06/10)
A series of novel N-alkylated C-6-isobutyl- or -propyl pyrimidine derivatives were synthesized and their antiproliferative effect was evaluated on a panel of tumor cell lines including leukemia cell line K562 and normal diploid human fibroblasts. N-methox
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: New lead structures for monitoring gene expression in vivo
Martic, Miljen,Pernot, Lucile,Westermaier, Yvonne,Perozzo, Remo,Kraljevic, Tatjana Gazivoda,Kristafor, Svjetlana,Raic-Malic, Silvana,Scapozza, Leonardo,Ametamey, Simon
, p. 293 - 315 (2012/02/03)
Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is