3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione

Base Information

• Chemical Name: 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione
• CAS No.: 444045-54-9
• Molecular Formula: C₁₆H₁₇Cl₂N₃O₅S
• Molecular Weight: 434.3

Synonyms:3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione

Chemical Property of 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione

Chemical Property:

Purity/Quality:

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Technology Process of 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione

There total 9 articles about 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-Amino-3-chloro-2-(4-methyl-[1,4]diazepane-1-sulfonyl)-phenol (444045-53-8) + 3,4-Dichlorocyclobut-3-ene-1,2-dione (2892-63-9) + MCPA (94-74-6) → 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione (444045-54-9)

Guidance literature:

In tetrahydrofuran;

Reference yield:

1-Methylhomopiperazine (4318-37-0) → 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione (444045-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂

2: NaH; H₂O / tetrahydrofuran

3: H₂ / Pt/C

4: tetrahydrofuran / 20 °C

With water; hydrogen; sodium hydride; triethylamine; platinum on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.12.067

Reference yield:

2,6-dichloro-3-nitrobenzenesulfonyl chloride (276702-53-5) → 3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione (444045-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂

2: NaH; H₂O / tetrahydrofuran

3: H₂ / Pt/C

4: tetrahydrofuran / 20 °C

With water; hydrogen; sodium hydride; triethylamine; platinum on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.12.067

upstream raw materials:

6-Amino-3-chloro-2-(4-methyl-[1,4]diazepane-1-sulfonyl)-phenol

3,4-Dichlorocyclobut-3-ene-1,2-dione

1-Methylhomopiperazine

2,6-dichloro-3-nitrobenzenesulfonyl chloride

Downstream raw materials:

3-[4-Chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-4-phenylamino-cyclobut-3ene-1,2-dione

biphenyl

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