C₁₃H₁₂FNO₃

Base Information

• Chemical Name: C₁₃H₁₂FNO₃
• CAS No.: 500367-11-3
• Molecular Formula: C₁₃H₁₂FNO₃
• Molecular Weight: 249.242
• Mol file: 500367-11-3.mol

Synonyms:C₁₃H₁₂FNO₃

Chemical Property of C₁₃H₁₂FNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₂FNO₃

There total 4 articles about C₁₃H₁₂FNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + 1-chloromethyl-4-fluorobenzene (352-11-4) → C13H12FNO3 (500367-11-3) + ethyl 2-(4-fluorobenzyl)oxazole-4-carboxylate (500367-20-4)

Guidance literature:

With palladium diacetate; caesium carbonate; CyJohnPhos; In 1,4-dioxane; at 110 ℃; for 18h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/b816374j

Reference yield: 65.0%

Ethyl isocyanoacetate (2999-46-4) + p-Fluorophenylacetic acid (405-50-5) → C13H12FNO3 (500367-11-3)

Guidance literature:

Ethyl isocyanoacetate; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

p-Fluorophenylacetic acid; In tetrahydrofuran; at 0 ℃; for 1h;

With ammonium chloride; water; In tetrahydrofuran;

Reference yield:

ethyl 2-cyanoacetate (105-56-6) + 4-Fluorophenylacetyl chloride (459-04-1) → C13H12FNO3 (500367-11-3)

Guidance literature:

With potassium tert-butylate;

upstream raw materials:

p-Fluorophenylacetic acid

ethyl 2-cyanoacetate

4-Fluorophenylacetyl chloride

Ethyl isocyanoacetate

Downstream raw materials:

1-amino-3-(4-fluorophenyl)propan-2-one hydrochloride

C₁₁H₈FNO₃