1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole

Base Information

• Chemical Name: 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole
• CAS No.: 1285561-73-0
• Molecular Formula: C₁₂H₁₂FN₃O₃
• Molecular Weight: 265.244
• Mol file: 1285561-73-0.mol

Synonyms:1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole

Chemical Property of 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole

There total 3 articles about 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Fluorophenol (371-41-5) + toluene-4-sulfonic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester (30575-42-9) → 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole (1285561-73-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1016/j.bmc.2018.12.003

Reference yield:

4-Fluorophenol (371-41-5) + metronidazole (443-48-1) → 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole (1285561-73-0)

Guidance literature:

With triphenylphosphine tagged with poly-(ethyleneglycol)-ω-monomethyl ether; diethyl azodicarboxylate tagged with poly-(ethyleneglycol)-ω-monomethyl ether; In tetrahydrofuran; for 20h; Inert atmosphere;

DOI:10.1021/co100091n

Reference yield:

metronidazole (443-48-1) → 1-(2-(4-fluorophenoxy)ethyl)-2-methyl-5-nitro-1H-imidazole (1285561-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / chloroform / 24 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

With pyridine; potassium carbonate; In chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2018.12.003

upstream raw materials:

4-Fluorophenol

metronidazole

toluene-4-sulfonic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester