N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide

Base Information

• Chemical Name: N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide
• CAS No.: 1236282-84-0
• Molecular Formula: C₂₄H₂₅Cl₂IN₄O
• Molecular Weight: 583.299

Synonyms:N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide

Chemical Property of N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide

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Technology Process of N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide

There total 1 articles about N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5-iodo-2-isopropyl-6-methyl-pyrimidin-4-ol (69696-38-4) + p-chlorobenzylisocyanide (39546-47-9) + 4-chlorobenzylamine (104-86-9) → N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide (1236282-84-0)

Guidance literature:

In methanol; at 60 ℃; for 72h; Inert atmosphere;

DOI:10.1021/jo100759b

Reference yield: 75.0%

N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide (1236282-84-0) + phenylacetylene (536-74-3) → N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-acetamide (1236283-06-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃;

DOI:10.1021/jo100759b

Reference yield: 64.0%

N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-acetamide (1236282-84-0) + 1-ethynyl-2-(trifluoromethyl)benzene (704-41-6) → N-(4-chlorobenzyl)-2-{(4-chlorobenzyl)-[2-isopropyl-6-methyl-5-(2-trifluoromethylphenylethynyl)-pyrimidin-4-yl]-amino}-acetamide (1236283-08-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃;

DOI:10.1021/jo100759b

upstream raw materials:

formaldehyd

5-iodo-2-isopropyl-6-methyl-pyrimidin-4-ol

p-chlorobenzylisocyanide

4-chlorobenzylamine

Downstream raw materials:

N-(4-chlorobenzyl)-2-{(4-chlorobenzyl)-[2-isopropyl-6-methyl-5-(2-trifluoromethylphenylethynyl)-pyrimidin-4-yl]-amino}-acetamide

N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-acetamide

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