4-(diphenylphosphino)acetophenone

Base Information

• Chemical Name: 4-(diphenylphosphino)acetophenone
• CAS No.: 5032-64-4
• Molecular Formula: C₂₀H₁₇OP
• Molecular Weight: 304.328
• Mol file: 5032-64-4.mol

Synonyms:4-(diphenylphosphino)acetophenone

Chemical Property of 4-(diphenylphosphino)acetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(diphenylphosphino)acetophenone

There total 21 articles about 4-(diphenylphosphino)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

H3B(PPh2(C6H4COCH3)) (1257322-27-2) → 4-(diphenylphosphino)acetophenone (5032-64-4)

Guidance literature:

In tetrahydrofuran; methanol; for 96h; Inert atmosphere; Molecular sieve; Reflux;

DOI:10.1016/j.jorganchem.2010.08.026

Reference yield: 87.0%

4-Iodoacetophenone (13329-40-3) + diphenylphosphane (829-85-6) → 4-(diphenylphosphino)acetophenone (5032-64-4)

Guidance literature:

With potassium acetate; In N,N-dimethyl acetamide; at 130 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.jorganchem.2018.04.018

Reference yield: 86.0%

1-(4-(diphenylphosphoryl)phenyl)ethan-1-one (5032-76-8) → 4-(diphenylphosphino)acetophenone (5032-64-4)

Guidance literature:

With diethoxymethylane; Bis(p-nitrophenyl) phosphate; In toluene; at 110 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja3069165

upstream raw materials:

para-bromoacetophenone

(trimethylsilyl)diphenylphosphine

1-bromo-4-methoxy-benzene

triphenylphosphine

Downstream raw materials:

1-(4-(diphenylphosphoryl)phenyl)ethan-1-one

1-{4-(diphenylthiophosphinyl)phenyl}ethanone