Ethanone, 1-[4-(diphenylphosphinyl)phenyl]-

Base Information

• Chemical Name: Ethanone, 1-[4-(diphenylphosphinyl)phenyl]-
• CAS No.: 5032-76-8
• Molecular Formula: C20H17O2P
• Molecular Weight: 320.328
• Mol file: 5032-76-8.mol

Synonyms:

Chemical Property of Ethanone, 1-[4-(diphenylphosphinyl)phenyl]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[4-(diphenylphosphinyl)phenyl]-

There total 19 articles about Ethanone, 1-[4-(diphenylphosphinyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Diphenylphosphine oxide (4559-70-0) + 1,1,2,2,3,3,4,4,4-nonafluoro-butane-1-sulfonic acid 4-acetyl-phenyl ester (264135-62-8) → 1-(4-(diphenylphosphoryl)phenyl)ethan-1-one (5032-76-8)

Guidance literature:

With palladium diacetate; triethylamine; sodium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 4h; Inert atmosphere; Microwave irradiation; Heating; Sealed tube;

DOI:10.1021/acs.joc.1c02172

Reference yield: 95.0%

para-bromoacetophenone (99-90-1) + Diphenylphosphine oxide (4559-70-0) → 1-(4-(diphenylphosphoryl)phenyl)ethan-1-one (5032-76-8)

Guidance literature:

With potassium phosphate; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In 1,4-dioxane; at 100 ℃; Inert atmosphere;

DOI:10.1002/chem.201103723

Reference yield: 93.0%

4-Iodoacetophenone (13329-40-3) + Diphenylphosphine oxide (4559-70-0) → 1-(4-(diphenylphosphoryl)phenyl)ethan-1-one (5032-76-8)

Guidance literature:

With copper(l) iodide; C₁₄H₁₄N₂O₃; potassium carbonate; In isopropyl alcohol; at 120 ℃; for 10h; Inert atmosphere; Schlenk technique;

DOI:10.1002/cjoc.202100354

upstream raw materials:

4-(diphenylphosphino)acetophenone

(p-acetylphenyl)triphenylphosphonium bromide

-butyl vinyl ether

(4-bromophenyl)diphenylphosphine oxide

Downstream raw materials:

4-(diphenylphosphino)acetophenone

Refernces

• 1、 Zhu, Da-Liang,Jiang, Shan,Wu, Qi,Wang, Hao,Chai, Lu-Lu,Li, Hai-Yan,Li, Hong-Xi. "Visible-Light-Induced Nickel-Catalyzed P(O)-C(sp2) Coupling Using Thioxanthen-9-one as a Photoredox Catalysis". supporting information. p. 160 - 165. Retrieved 2021/01/09.
• 2、 Henyecz, Réka,Huszár, Bianka,Keglevich, Gy?rgy,Mucsi, Zoltán. "Microwave assisted P–C coupling reactions without directly added P-ligands". . . Retrieved 2021/12/24.