N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

Base Information

Chemical Name:N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide
CAS No.:1315585-12-6
Molecular Formula:C₂₆H₃₀N₁₀O₂S
Molecular Weight:546.656
Hs Code.:

N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

Synonyms:N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

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Chemical Property of N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

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Technology Process of N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

There total 10 articles about N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1334320-78-3
C₂₀H₂₀N₈OS

: 7693-46-1
4-Nitrophenyl chloroformate

: 1315585-12-6
N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

Guidance literature:: C₂₀H₂₀N₈OS; 4-Nitrophenyl chloroformate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

1-methyl-piperazine; In tetrahydrofuran;

Reference yield:

: 1160995-45-8
2,4-dichloro-6-nitropyrrolo[2,1-f][1,2,4]triazine

: 1315585-12-6
N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

3.1: hydrogen / Raney nickel / tetrahydrofuran; methanol

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; potassium iodide; Raney nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1204245-52-2
1-amino-4-nitro-1H-pyrrole-2-carboxamide

: 1315585-12-6
N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 1,4-dioxane / 1 h / Reflux

2.1: triethylamine; trichlorophosphate / Inert atmosphere; Reflux

3.1: potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 2 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran; methanol

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogen; potassium carbonate; triethylamine; potassium iodide; trichlorophosphate; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;