1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

Base Information

Chemical Name:1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride
CAS No.:113113-19-2
Molecular Formula:C₁₉H₃₀N₆S*2ClH
Molecular Weight:447.475
Hs Code.:

Synonyms:1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

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Chemical Property of 1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

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Technology Process of 1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

There total 3 articles about 1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 109-55-7
1-amino-3-(dimethylamino)propane

: 113113-25-0
1-n-butyl-3-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>thiourea

: 113113-19-2
1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

Guidance literature:: With hydrogenchloride; mercury(II) oxide; In butan-1-ol; at 60 - 65 ℃; for 1.5h;
DOI:10.1021/jm00400a004

Reference yield:

: 113113-54-5
S-methyl <5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>dithiocarbamate

: 113113-19-2
1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / butan-1-ol / 16 h / Heating

2: 63 percent / 1.) mercury(II) oxide, 2.) 2 N HCl / butan-1-ol / 1.5 h / 60 - 65 °C

With hydrogenchloride; mercury(II) oxide; In butan-1-ol;
DOI:10.1021/jm00400a004

Reference yield:

: 59565-54-7
5-(2-methylphenyl)-1,3,4-thiadiazol-2-amine

: 113113-19-2
1-n-butyl-3-<3-(dimethylamino)propyl>-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KOH / 1.) DMF, room temperature, 18 h, 2.) MeOH, reflux, 45 min

2: 70 percent / butan-1-ol / 16 h / Heating

3: 63 percent / 1.) mercury(II) oxide, 2.) 2 N HCl / butan-1-ol / 1.5 h / 60 - 65 °C

With hydrogenchloride; potassium hydroxide; mercury(II) oxide; In butan-1-ol;
DOI:10.1021/jm00400a004