Dimethyl pyrazine-2,6-dicarboxylate

Base Information

Chemical Name:Dimethyl pyrazine-2,6-dicarboxylate
CAS No.:35042-26-3
Molecular Formula:C8H8 N2 O4
Molecular Weight:196.163
Hs Code.:2933990090
DSSTox Substance ID:DTXSID80563289
Nikkaji Number:J344.777D
Wikidata:Q82447699
Mol file:35042-26-3.mol

Synonyms:Dimethyl pyrazine-2,6-dicarboxylate;35042-26-3;PYRAZINE-2,6-DICARBOXYLIC ACID DIMETHYL ESTER;2,6-DIMETHYL PYRAZINE-2,6-DICARBOXYLATE;SCHEMBL69342;2,6-dimethoxycarbonylpyrazine;DTXSID80563289;RSXGKDUYJPQZTL-UHFFFAOYSA-N;AKOS006290535;E83618;EN300-8583720

Suppliers and Price of Dimethyl pyrazine-2,6-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of Dimethyl pyrazine-2,6-dicarboxylate

Chemical Property:

Melting Point:119-120 °C
Boiling Point:302.3±37.0 °C(Predicted)
PKA:-2.28±0.10(Predicted)
PSA：78.38000
Density:1.293±0.06 g/cm3(Predicted)
LogP:0.04980
XLogP3:-0.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:196.04840674
Heavy Atom Count:14
Complexity:209

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CN=CC(=N1)C(=O)OC

Technology Process of Dimethyl pyrazine-2,6-dicarboxylate

There total 6 articles about Dimethyl pyrazine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 4774-14-5
2,6-dichloropyrazine

: 35042-26-3
dimethyl pyrazine-2,6-dicarboxylate

Guidance literature:: With ethyl azide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; at 120 ℃; for 16h; under 29420.3 Torr;
DOI:10.1055/s-1990-27055

Reference yield:

: 108-50-9
2,6-dimethylpyrazine

: 35042-26-3
dimethyl pyrazine-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: selenium(IV) oxide / pyridine; water / 12 h / Reflux

2: thionyl chloride / 3 h / Reflux

With selenium(IV) oxide; thionyl chloride; In pyridine; water;
DOI:10.1039/c6ce00276e

Reference yield:

: 23611-75-8
6-chloro-pyrazine-2-carboxylic acid methyl ester

: 35042-26-3
dimethyl pyrazine-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h

1.2: 20 h / Reflux

2.1: lithium carbonate / 0.5 h

2.2: 3 h / 0 °C

With lithium carbonate; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1039/c2nj40791d