4-ethylbutyrophenone

Base Information

• Chemical Name: 4-ethylbutyrophenone
• CAS No.: 35028-11-6
• Molecular Formula: C12H16 O
• Molecular Weight: 176.258
• Hs Code.: 2914399090
• Mol file: 35028-11-6.mol

Synonyms:Butyrophenone,p-ethyl- (4CI); 4'-Ethylbutyrophenone

Chemical Property of 4-ethylbutyrophenone

Chemical Property:

• Boiling Point: 142-143 °C(Press: 13 Torr)
• PSA: 17.07000
• Density: 0.943±0.06 g/cm3(Predicted)
• LogP: 3.44960

Purity/Quality:

98% ^*data from raw suppliers

1-(4-Ethyl-phenyl)-butan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethylbutyrophenone

There total 10 articles about 4-ethylbutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethylbenzene (100-41-4,27536-89-6) + butyryl chloride (141-75-3) → 1-(4-ethylphenyl)butan-1-one (35028-11-6)

Guidance literature:

butyryl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

ethylbenzene; In 1,2-dichloro-ethane; at 50 ℃; for 1h;

DOI:10.1039/c5ob00684h

Reference yield: 83.0%

formic acid (64-18-6) + 4-ethyl-1-iodobenzene (25309-64-2) + propyl bromide (106-94-5) → 1-(4-ethylphenyl)butan-1-one (35028-11-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic anhydride; magnesium; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; at 55 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201800879

Reference yield: 39.0%

hex-3-yne (928-49-4) + 4-vinyl-benzaldehyde (1791-26-0) → 1-(4-Vinyl-phenyl)-butan-1-one (24993-84-8) + C15H20O2 (1206831-83-5) + 1-(4-ethylphenyl)butan-1-one (35028-11-6)

Guidance literature:

With 3-methylpyridin-2-ylamine; Wilkinson's catalyst; 4-trifluoromethylbenzoic acid; water; cyclohexylamine; In toluene; at 130 ℃; for 72h;

DOI:10.1055/s-0029-1218000

upstream raw materials:

N,N,N,N,N,N-hexamethylphosphoric triamide

ethylbenzene

butyryl chloride

hex-3-yne

Downstream raw materials:

1-(4-Ethyl-phenyl)-butane-1,2-dione dioxime

Refernces

• 1、 Siddaraju, Yogesh,Prabhu, Kandikere Ramaiah. "Iodine promoted α-hydroxylation of ketones". supporting information. p. 6749 - 6753. Retrieved 2015/06/25.
• 2、 Kimura, Norio,Takamuku, Setsuo. "Mechanistic evaluation of dissociative electron-transfer and nucleophilic substitution reactions". . p. 4087 - 4088. Retrieved 2007/10/02.