2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

Base Information

Chemical Name:2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester
CAS No.:158387-23-6
Molecular Formula:C₅₂H₅₆ClN₅O₆
Molecular Weight:882.5
Hs Code.:

2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

Synonyms:2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

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Chemical Property of 2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

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Technology Process of 2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

There total 4 articles about 2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 95853-92-2
3-(5-carboxypentyl)-5-chloro-1-methyl-2-(pyridin-3-yl)indole

: 6-amino-2-<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>hexanoic acid benzyl ester

: 158387-23-6
2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 16h;
DOI:10.1021/jm00038a011

Reference yield:

: 100-39-0
benzyl bromide

: 158387-23-6
2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 90 percent / HCl / ethyl acetate / 16 h

3: 52 percent / triethylamine, 1-<3-(dimethylamino)propyl>-2-ethylcarbodiimide hydrochloride (EDCl) / CH₂Cl₂ / 16 h

With hydrogenchloride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a011

Reference yield:

: 97878-50-7
(S)-6-tert-Butoxycarbonylamino-2-((S)-1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-hexanoic acid

: 158387-23-6
2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 90 percent / HCl / ethyl acetate / 16 h

3: 52 percent / triethylamine, 1-<3-(dimethylamino)propyl>-2-ethylcarbodiimide hydrochloride (EDCl) / CH₂Cl₂ / 16 h

With hydrogenchloride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a011