5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

Base Information

Chemical Name:5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide
CAS No.:1215105-44-4
Molecular Formula:C₃₀H₂₂ClFN₄O₃
Molecular Weight:540.981
Hs Code.:

Synonyms:5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

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Chemical Property of 5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

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Technology Process of 5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

There total 8 articles about 5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylic acid

: 74-89-5
methylamine

: 1215105-44-4
5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1215105-44-4
5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 2 h / 90 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 180 °C / Microwave irradiation

3: N-Bromosuccinimide / tetrahydrofuran / 20 °C

4: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 7757.43 Torr / Parr bomb

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

6: sodium hydroxide; water / methanol / 1 h / 60 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

With N-Bromosuccinimide; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; palladium diacetate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1215106-68-5
5-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridine

: 1215105-44-4
5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 180 °C / Microwave irradiation

2: N-Bromosuccinimide / tetrahydrofuran / 20 °C

3: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 7757.43 Torr / Parr bomb

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

5: sodium hydroxide; water / methanol / 1 h / 60 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

With N-Bromosuccinimide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;